Denis Vlasenko is rapidly emerging as one of the brightest Russian conductors of his generation. He began his education at the Moscow Chorus Academy, followed by the Moscow State Conservatory, finalizing his studies at the St. Petersburg State Conservatory. Subsequently he was appointed  Permanent Conductor at the “New Russia State Symphony Orchestra” in Moscow.

Vlasenko is working regularly with many great artists, such as: Anna Netrebko, Yuri Bashmet, Vadim Repin, Denis Matsuev, Aida Garifullina, Nikolai Lugansky, Sergey Krylov, Maria Guleghina, Ludovic Tezier, Hibla Gerzmava, Dmitry Korchak, Lucas Debargue, Erwin Shrott, Joseph Calleja and many others.  He has been in increasing demand elsewhere in Europe and Asia where engagements include the Tokyo Philharmonic Orchestra, Moscow and Saint-Petersburg Philharmonic orchestras, European symphony orchestra (Gibraltar), The National Philharmonic orchestra of Russia, Russian National Orchestra, Orchestra del Teatro Comunale di Bologna, Orchestra I Pomeriggi Musicali di Milano, Latvian National Symphony Orchestra, Brussels Philharmonic, Latvian National Symphony, Tatarstan Symphony orchestra, Muenster Symphony.

Equally adept in the opera world he became the first Russian conductor to perform at the “Rossini Opera Festival” (Pesaro) with “Il viaggio a Reims”  and "L`inganno felice".  Recent successes  include: Concerts with Anna Netrebko and Yusif Eyvazov at Teatro Real (Madrid) and Gran Teatro del Liceu (Barcelona), “Turandot” at Teatro Petruzzelli (Bari), 3 productions of “La traviata”  at the Palacio de Bellas Artes (Mexico City), at the "Mikhailovsky" Theatre (Sain-Petersburg) and at the Azerbaijan state opera Theatre (Baku), “Eugeny Onegin” at the Latvian National Opera (Riga), “Le Comte Ory” by Rossini in Tokyo, "Lucia di Lammermoor" at  Teatro Calderon (Valladolid), "Il barbiere di Siviglia" at the Kolobov Moscow opera Theatre, "Aida" at the Khvorostovsky opera Theatre (Krasnoyarsk), "La fille du regiment" by Donizetti at Elena Obraztsova Festival in Great hall of the Moscow Conservatory and Gala concert at Bolshoi Theatre (Moscow). 

He also recorded music for Opening Ceremony and Closing-Ceremony of the Winter Olimpic Games in Sochi-2014. In 2016-2017 he is a main conductor of the 4th season of popular Russian TV Show "Great Opera" on channel "Kultura".

From September 2018 Denis Vlasenko has invited to lead "Operatic and symphonic Conducting" course at the Popov Academy of Choral Art in Moscow. 

In 2021-2022 conducts big russian tour of Anna Netrebko and Yusif Eyvazov.

From January 2022 Denis Vlasenko appointed to position of Artistic Director and Chief Conductor  of the Great Theatre of the Opera and Ballet named A.Navoi in Tashkent (Uzbekistan).